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FGH10019

Cat. No. M9495
FGH10019 Structure
Size Price Availability Quantity
5mg USD 387  USD387 In stock
10mg USD 555  USD555 In stock
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Quality Control & Documentation
Biological Activity

FGH10019 is a novel SREBP (sterol regulatory element-binding protein) inhibitor, with IC50 of 1 μM.

Chemical Information
Molecular Weight 373.49
Formula C18H19N3O2S2
CAS Number 1046045-61-7
Form Solid
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kamisuki S, et al. J Med Chem. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.

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