Ferulic acid is a chemopreventive caffeic acid analogue. Ferulic acid is an inhibitor of 5-LO (5-lipoxygenase) and 12-LO (12-lipoxygenase).
Molecular Weight | 194.18 |
Formula | C10H10O4 |
CAS Number | 1135-24-6 |
Solubility (25°C) | DMSO 30 mg/mL |
Storage | 2-8°C, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Dan Li, et al. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives
[5] Kamila Zduńska, et al. Antioxidant Properties of Ferulic Acid and Its Possible Application
Related FGFR Products |
---|
LY-3076226
LY-3076226 is an antibody drug coupling (ADC) with a cleavable linker targeting FGFR2. |
Aprutumab ixadotin
Aprutumab ixadotin is an antibody drug coupling (ADC) with a non-cleavable linker that targets FGFR2. |
Gunagratinib
Gunagratinib is an orally active, potent, selective, and irreversible fibroblast growth factor receptor (pan-FGFR) inhibitor for use in cancer research. |
SAR-442501
SAR-442501 is a novel anti-FGFR3 monoclonal antibody for studies related to achondroplasia (ACH). |
TYRA-200
TYRA-200 is an FGFR1/2/3 (FGFR2 mutation) inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.