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Fenbufen

Cat. No. M5639
Fenbufen Structure
Synonym:

Lederfen, CL-82204

Size Price Availability Quantity
100mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 254.28
Formula C16H14O3
CAS Number 36330-85-5
Purity >99%
Solubility 50 mg/mL in DMSO
Storage at -20°C
References

Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria.
Syed M, et al. Toxicol In Vitro. 2016 Mar;31:23-9. PMID: 26612354.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Fenbufen, Lederfen, CL-82204 supplier, COX, inhibitors

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