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F1063-0967

Cat. No. M9467
F1063-0967 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 60 In stock
10mg USD 90 In stock
50mg USD 250 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

F1063-0967 is a novel inhibitor of dual-specificity phosphatase 26 (DUSP26) with an IC50 of 11.62 μM, inducing apoptosis in IMR-32 cell line. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has little inhibition effect on SH-SY5Y cell line.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 484.59
Formula C24H24N2O5S2
CAS Number 613225-56-2
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking.
Ren JX, et al. Biomed Pharmacother. 2017 May;89:376-385. PMID: 28249240.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: F1063-0967 supplier, Phosphatase, inhibitors

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