Free shipping on all orders over $ 500

EXP-3174

Cat. No. M8935
EXP-3174 Structure
Size Price Availability Quantity
10mg USD 100 In stock
25mg USD 200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 produced a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 436.9
Formula C22H21ClN6O2
CAS Number 124750-92-1
Purity >98%
Solubility DMSO
Storage at -20°C
References

Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats.
Choi JS, et al. Pharmazie. 2013 Nov;68(11):882-8. PMID: 21709429.

Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Yang SH, et al. Pharmacology. 2011;88(1-2):1-9. PMID: 21709429.

Related Products
YM-90709

YM-90709 is an interleukin-5 receptor antagonist.

HUHS015

HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells.

1-methoxy PMS

1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.

EPO

Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia.

IFNγ

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EXP-3174 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.