EXP-3174, also known as Losartan Carboxylic Acid, is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. EXP-3174 produced a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats.
Choi JS, et al. Pharmazie. 2013 Nov;68(11):882-8. PMID: 21709429.
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Yang SH, et al. Pharmacology. 2011;88(1-2):1-9. PMID: 21709429.
YM-90709 is an interleukin-5 receptor antagonist.
HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells.
1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia.
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
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