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Etonogestrel

Cat. No. M5635
Etonogestrel Structure
Synonym:

Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel

Size Price Availability Quantity
5mg USD 54  USD60 In stock
10mg USD 69.3  USD77 In stock
50mg USD 279  USD310 In stock
100mg USD 432  USD480 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 324.46
Formula C22H28O2
CAS Number 54048-10-1
Purity >98%
Solubility 64 mg/mL in DMSO
Storage at -20°C
References

Use of the etonogestrel implant and levonorgestrel intrauterine device beyond the U.S. Food and Drug Administration-approved duration.
McNicholas C, et al. Obstet Gynecol. 2015 Mar;125(3):599-604. PMID: 25730221.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Etonogestrel, Implanon, Nexplanon, 3-Oxodesogestrel, 3-keto-Desogestrel supplier, Estrogen Receptor, inhibitors

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