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Estrone

Cat. No. M3945
Estrone Structure
Synonym:

E1,oestrone; Aquacrine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 36  USD40 In stock
100mg USD 27  USD30 In stock
500mg USD 40.5  USD45 In stock
1g USD 54  USD60 In stock
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Quality Control
Biological Activity

Estrone is an estrogenic hormone secreted by the ovary as well as adipose tissue.Estrone is one of several natural estrogens, which also include estriol and estradiol.Estrone is the least abundant of the three hormones,estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative.Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol.Estrone is known to be a carcinogen for human females as well as cause breast tenderness or pain, nausea, headache, hypertension, and leg cramps.In men, estrone has been known to cause anorexia, nausea, vomiting, and erectile dysfunction.It is the predominant estrogen in postmenopausal women.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 270.37
Formula C18H22O2
CAS Number 53-16-7
Purity 99.87%
Solubility DMSO 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Estrone, E1,oestrone; Aquacrine supplier, Estrogen Receptor, inhibitors

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