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Esomeprazole Magnesium trihydrate

Cat. No. M6194
Esomeprazole Magnesium trihydrate Structure
Size Price Availability Quantity
50mg USD 165 In stock
100mg USD 300 In stock
200mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Esomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

Cell Experiment
Cell lines SCC cell line
Preparation method For viability assays, cells were plated onto 96-well plates and allowed to attach for 24 hours (SCC) or 48 hours (EAC). Then, phenol red free medium containing esomeprazole at various concentrations was freshly prepared and added to the corresponding cells.
Concentrations 50 μM
Incubation time 72 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 767.17
Formula C34H42MgN6O9S2
CAS Number 217087-09-7
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer.
Lindner K, et al. J Exp Clin Cancer Res. 2014 Sep 1;33:73. PMID: 25175076.

Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets.
Kan SL, et al. Drug Deliv. 2016;23(3):866-73. PMID: 24892629.

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Keywords: Esomeprazole Magnesium trihydrate supplier, Autophagy, inhibitors

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