Esomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.
|Cell lines||SCC cell line|
|Preparation method||For viability assays, cells were plated onto 96-well plates and allowed to attach for 24 hours (SCC) or 48 hours (EAC). Then, phenol red free medium containing esomeprazole at various concentrations was freshly prepared and added to the corresponding cells.|
|Incubation time||72 h|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer.
Lindner K, et al. J Exp Clin Cancer Res. 2014 Sep 1;33:73. PMID: 25175076.
Preparation and in vitro/in vivo evaluation of esomeprazole magnesium-modified release pellets.
Kan SL, et al. Drug Deliv. 2016;23(3):866-73. PMID: 24892629.
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