Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM.
Molecular Weight | 288.25 |
Formula | C15H12O6 |
CAS Number | 552-58-9 |
Solubility (25°C) | 10 mM in DMSO |
Storage | 2-8°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Shu Wen, et al. Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
[5] Anowarul Islam, et al. The pharmacological and biological roles of eriodictyol
Related Immunology/Inflammation Products |
---|
Naringenin
Naringenin is the predominant flavanone in Citrus reticulata Blanco, it displays strong anti-inflammatory and antioxidant activities. Naringenin has anti-dengue virus (DENV) activity. |
BK50164
BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. |
CCT374705
CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. |
Mycophenolate Sodium
Mycophenolate Sodium is a Mycophenolic acid precursor, as well as an inhibitor of T-lymphocyte proliferation and an inhibitor of inosine monophosphate dehydrogenase (IMPDH). |
Efgartigimod
Efgartigimod (ARGX-113) is a human IgG1 antibody Fc-derived fragment and an Fc receptor antagonist that can be used in studies related to autoimmune diseases such as myasthenia gravis (MG), primary immune thrombocytopenia (ITP), and others. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.