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EPZ004777 hydrochloride

Cat. No. M2675
EPZ004777 hydrochloride  Structure
Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 180  USD180 In stock
25mg USD 320  USD320 In stock
50mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

EPZ004777 hydrochloride is the hydrochloride salt of EPZ004777, which is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.

Chemical Information
Molecular Weight 576.13
Formula C28H41N7O4.HCl
CAS Number 1380316-03-9
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




Keywords: EPZ004777 hydrochloride supplier, Histone Methyltransferase, inhibitors, activators


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