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ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant capacity.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 454.47 |
| Formula | C28H22O6 |
| CAS Number | 62218-08-0 |
| Purity | >98% |
| Solubility | |
| Storage | at -20°C |
| Related Cytochrome P450 (e.g. CYP17) Products |
|---|
| Tebuconazole
Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively. |
| Uniconazole
Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols. |
| Dihydromethysticin
Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity. |
| Bergaptol
Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. |
| Rhapontigenin
Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM. |
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