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Eprodisate disodium

Cat. No. M5618
Eprodisate disodium Structure
Synonym:

NC-503

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100mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Eprodisate Disodium is the orally available disodium salt form of Eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis.

Chemical Information
Molecular Weight 248.19
Formula C3H6Na2O6S2
CAS Number 36589-58-9
Form Solid
Solubility (25°C) 49 mg/mL in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bayes M, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials.

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Keywords: Eprodisate disodium, NC-503 supplier, Amyloid, inhibitors, activators


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