Free shipping on all orders over $ 500

EPO

Cat. No. M9241
EPO Structure
Synonym:

Erythropoietin

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia. EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signalling cascade. This initiates the STAT5, PIK3 and Ras MAPK pathways. This results in differentiation, survival and proliferation of the erythroid cell.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity
Solubility
Storage at -20°C
References

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.
Middleton SA, et al. J Biol Chem. 1999 May 14;274(20):14163-9. PMID: 10318834.

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Livnah O, et al. Nat Struct Biol. 1998 Nov;5(11):993-1004. PMID: 9808045.

Related Products
S107

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer.

TMB

3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

Coelenterazine

Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.

Fluorescein

Fluorescein is a synthetic organic compound and dye.

SBI-0640756

SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EPO, Erythropoietin supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.