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EPO

Cat. No. M9241
EPO Structure
Synonym:

Erythropoietin

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Biological Activity

Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia. EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signalling cascade. This initiates the STAT5, PIK3 and Ras MAPK pathways. This results in differentiation, survival and proliferation of the erythroid cell.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity
Solubility
Storage at -20°C
References

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.
Middleton SA, et al. J Biol Chem. 1999 May 14;274(20):14163-9. PMID: 10318834.

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Livnah O, et al. Nat Struct Biol. 1998 Nov;5(11):993-1004. PMID: 9808045.

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Abmole Inhibitor Catalog 2017




Keywords: EPO, Erythropoietin supplier, inhibitors

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