Epigoitrin is extracted from I. indigotica Fort. roots.
 |
Source | J Tradit Chin Med (2016). Figure 2. Epigoitrin |
| Method | MTT assay | |
| Cell Lines | MDCK cells | |
| Concentrations | 50 μg/mL | |
| Incubation Time | 72 h | |
| Results | Additionally, the protective effect of CB, epigoitrin, PEP and PEP+ ALK+OA fractions was not dose-dependent. |
| Cell Experiment | |
|---|---|
| Cell lines | MDCK cells |
| Preparation method | For those compounds which cannot be dissolved in the medium, they were first dissolved in DMSO and then diluted with the fresh medium. The final DMSO concentration in the medium was less than 1%. The concentration of CB and epigoitrin was 50 μg/mL and the initial concentration of PEP and PEP + ALK + OA was 100 μg/mL. |
| Concentrations | 50 μg/mL |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | |
| Formulation | |
| Dosages | |
| Administration | |
| Molecular Weight | 129.18 |
| Formula | C5H7NOS |
| CAS Number | 1072-93-1 |
| Solubility (25°C) | DMSO: ≥ 5 mg/mL (Need ultrasonic and warming) |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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