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Epiandrosterone

Cat. No. M2670
Epiandrosterone Structure
Synonym:

3β-androsterone, EpiA

Size Price Availability Quantity
10mM*1mL in DMSO USD 55  USD55 In stock
500mg USD 48  USD48 In stock
1g USD 58  USD58 In stock
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Quality Control & Documentation
Biological Activity

Epiandrosterone is a steroid hormone with weak androgenic activity, is a natural metabolite of DHEA.

Chemical Information
Molecular Weight 290.44
Formula C19H30O2
CAS Number 481-29-8
Solubility (25°C) DMSO 38 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vinod S Nair, et al. Evaluation of epiandrosterone as a long-term marker of testosterone use

[2] Laurie De Wilde, et al. Development and validation of a fast gas chromatography combustion isotope ratio mass spectrometry method for the detection of epiandrosterone sulfate in urine

[3] Shaoyong Ke, et al. Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone

[4] Lala El Kihel. Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports

[5] Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone

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Keywords: Epiandrosterone, 3β-androsterone, EpiA supplier, Androgen Receptor, inhibitors, activators


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