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Entrectinib (RXDX-101)

Cat. No. M5613
Entrectinib (RXDX-101) Structure
Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 125 In stock
50mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 560.64
Formula C31H34F2N6O2
CAS Number 1108743-60-7
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.
Farago AF, et al. J Thorac Oncol. 2015 Dec;10(12):1670-4. PMID: 26565381.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Entrectinib (RXDX-101) supplier, ALK, inhibitors

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