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Endoxifen E-isomer hydrochloride

Cat. No. M9796
Endoxifen E-isomer hydrochloride Structure
Synonym:

Endoxifen E-isomer HCl

Size Price Availability
25mg USD 540  USD600 1-2 Weeks
50mg USD 828  USD920 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 409.95
Formula C25H28ClNO2
CAS Number 1197194-61-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development
Benjamin M Ford, et al. PLoS One. 2016 Dec 9;11(12):e0167240. PMID: 27936172.

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  Catalog
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Keywords: Endoxifen E-isomer hydrochloride, Endoxifen E-isomer HCl supplier, Estrogen Receptor, inhibitors

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