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Endothelin-1 (human, porcine)

Cat. No. M9555
Endothelin-1 (human, porcine) Structure
Size Price Availability Quantity
1mg USD 260  USD260 In stock
2mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Endothelin-1 (human, porcine) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin-1 acts through two types of receptors ETA and ETB. ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion.

Chemical Information
Molecular Weight 2491.9
Formula C109H159N25O32S5
CAS Number 117399-94-7
Solubility (25°C) Soluble in water
Storage -20°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Agata Kowalczyk, et al. Arch Immunol Ther Exp (Warsz). The Role of endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis

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  Catalog
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Keywords: Endothelin-1 (human, porcine) supplier, Endothelin Receptor, inhibitors, activators


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