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EN6

Cat. No. M10277
EN6 Structure
Synonym:

ABM-4739

Size Price Availability Quantity
5mg USD 97  USD97 In stock
10mg USD 165  USD165 In stock
50mg USD 330  USD330 In stock
100mg USD 495  USD495 In stock
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Quality Control & Documentation
Biological Activity

EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy.

Chemical Information
Molecular Weight 368.34
Formula C19H14F2N4O2
CAS Number 1808714-73-9
Form Solid
Solubility (25°C) DMSO 4 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Clive Yik-Sham Chung, et al. Nat Chem Biol. Covalent targeting of the vacuolar H +-ATPase activates autophagy via mTORC1 inhibition

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Keywords: EN6, ABM-4739 supplier, Autophagy, inhibitors, activators


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