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Eliglustat

Cat. No. M5610
Eliglustat Structure
Synonym:

GENZ-112638

Size Price Availability Quantity
5mg USD 85.5  USD95 In stock
10mg USD 123.3  USD137 In stock
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Quality Control
Biological Activity

Eliglustat inhibits glucosylceramide synthase (GCS), thus reducing the load of glucosylceramide influx into the lysosome.

Product Citations
Customer Product Validations & Biological Datas
Source Nat Commun (2020), Figure 7, Eliglustat (Abmole Bioscience Inc.)
Method intraperitoneal injection
Cell Lines C57Bl/6N mice
Concentrations 60 mg/kg
Incubation Time 15 days
Results Metabolomics analysis of tumor tissues from all treatment groups showed that eliglustat was linked to reductions in glycosphingolipids in RM-9 tumor bearing mice
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 404.54
Formula C23H36N2O4
CAS Number 491833-29-5
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease.
Bennett LL, et al. Drug Des Devel Ther. 2015 Aug 18;9:4639-47. PMID: 26345314.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Eliglustat, GENZ-112638 supplier, inhibitors

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