Eliglustat inhibits glucosylceramide synthase (GCS), thus reducing the load of glucosylceramide influx into the lysosome.
Nat Commun. 2020 Aug 27;11(1):4279.
Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
Eliglustat purchased from AbMole
|Source||Nat Commun (2020), Figure 7, Eliglustat (Abmole Bioscience Inc.)|
|Cell Lines||C57Bl/6N mice|
|Incubation Time||15 days|
|Results||Metabolomics analysis of tumor tissues from all treatment groups showed that eliglustat was linked to reductions in glycosphingolipids in RM-9 tumor bearing mice|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 60 mg/mL|
Eliglustat tartrate for the treatment of adults with type 1 Gaucher disease.
Bennett LL, et al. Drug Des Devel Ther. 2015 Aug 18;9:4639-47. PMID: 26345314.
Forodesine hydrochloride is a potent and orally active transition-state analog inhibitor of purine nucleoside phosphorylase, with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP.
Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist.
EC5026 (BPN-19186) is a first-in-class, potent and orally active soluble inhibitor of Epoxide Hydrolase (sEH). EC5026 has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.
VPC-80051 is a novel inhibitor of hnRNP A1 that targets the hnRNP A1 RBD.
|D-Ribose 5-phosphate disodium
D-Ribose 5-phosphate disodium is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.