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Eletriptan hydrobromide

Cat. No. M2664
Eletriptan hydrobromide Structure
Synonym:

UK-116044

Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 80  USD80 In stock
50mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively.

Chemical Information
Molecular Weight 463.43
Formula C22H26N2O2S.HBr
CAS Number 177834-92-3
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Med Lett Drugs Ther. Drugs for Migraine

[2] No authors listed. Eletriptan

[3] Giorgio Sandrini, et al. Eletriptan

[4] Markus Frkkil, et al. Eletriptan review

[5] M J Gawel, et al. Eletriptan

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