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Elacridar (GF120918)

Cat. No. M5609
Elacridar (GF120918) Structure
Synonym:

GW120918

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 210 In stock
100mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Elacridar (GF120918) is a potent P-gp (MDR-1) and BCRP inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 563.64
Formula C34H33N3O5
CAS Number 143664-11-3
Purity >99%
Solubility 41 mg/mL in DMSO
Storage at -20°C
References

Brain distribution and bioavailability of elacridar after different routes of administration in the mouse.
Sane R, et al. Drug Metab Dispos. 2012 Aug;40(8):1612-9. PMID: 22611067.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Elacridar (GF120918), GW120918 supplier, P-gp, inhibitors

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