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EIPA hydrochloride

Cat. No. M14278
EIPA hydrochloride Structure
Synonym:

L593754 hydrochloride; MH 12-43 hydrochloride

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Quality Control & Documentation
Biological Activity

EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.

Chemical Information
Molecular Weight 336.22
CAS Number 1345839-28-2
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Adwait Kabra, et al. Superoxide dismutase C affects Dictyostelium contractile vacuole biogenesis and function

[2] H I Rocha-Gonzlez, et al. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception

[3] Xiang-Bin Kong, et al. Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients

[4] Fumitaka Kamachi, et al. Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors

[5] E L Renner, et al. Amiloride and amiloride analogs inhibit Na+/K+-transporting ATPase and Na+-coupled alanine transport in rat hepatocytes

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  Catalog
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Keywords: EIPA hydrochloride, L593754 hydrochloride; MH 12-43 hydrochloride supplier, TRP Channel, inhibitors, activators


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