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Efonidipine hydrochloride monoethanolate

Cat. No. M5607

Efonidipine hydrochloride monoethanolate Structure
Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Efonidipine(NZ-105) Hcl monoethanolate is a dual T-type and L-type calcium channel blocker (CCB).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 714.18
Formula C36H45ClN3O8P
CAS Number 111011-76-8
Purity >99%
Solubility 8.5 mg/mL in DMSO
Storage at -20°C
References

Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells.
Ikeda K, et al. Tohoku J Exp Med. 2011 Aug;224(4):263-71. PMID: 21757861.

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  Catalog
Abmole Inhibitor Catalog 2017




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