EDC.HCl Crosslinker is a zero-length crosslinker that can be used to conjugate carboxyl functional groups to primary amines. EDC.HCl is ideal for covalently binding proteins or peptides to carboxyl containing beads, resins, or other nanoparticals.
| Molecular Weight | 191.7 |
| Formula | C8H18ClN3 |
| CAS Number | 25952-53-8 |
| Solubility (25°C) | Water ≥ 30 mg/mL |
| Storage | -20°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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