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Ebastine

Cat. No. M2660
Ebastine Structure
Synonym:

LAS-W 090; RP64305

Size Price Availability Quantity
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Ebastinea is an orally active, potent histamine H1 receptor antagonist for studies related to allergic diseases.

Chemical Information
Molecular Weight 469.66
Formula C32H39NO2
CAS Number 90729-43-4
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Ebastine

[2] J Sastre. Ebastine in the Treatment of Allergic Rhinitis and Urticaria: 30 Years of Clinical Studies and Real-World Experience

[3] J Sastre. Ebastine in allergic rhinitis and chronic idiopathic urticaria

[4] M Hurst, et al. Ebastine: an update of its use in allergic disorders

[5] A J Moss, et al. Cardiac effects of ebastine and other antihistamines in humans

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Keywords: Ebastine, LAS-W 090; RP64305 supplier, Histamine Receptor, inhibitors, activators


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