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E3 ligase Ligand 2

Cat. No. M9832
E3 ligase Ligand 2 Structure
Synonym:

Thalidomide-4-OH; Cereblon ligand 2

Size Price Availability Quantity
50mg USD 180  USD180 In stock
100mg USD 300  USD300 In stock
500mg USD 900  USD900 In stock
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Quality Control & Documentation
Biological Activity

E3 ligase Ligand 2 (Thalidomide-4-OH) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein, it connected to the ligand for protein by a linker to form PROTACs.

Chemical Information
Molecular Weight 274.23
Formula C13H10N2O5
CAS Number 5054-59-1
Solubility (25°C) DMSO 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Megan G Marks, et al. Biol Pharm Bull. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation

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  Catalog
Abmole Inhibitor Catalog




Keywords: E3 ligase Ligand 2, Thalidomide-4-OH; Cereblon ligand 2 supplier, Ligand for E3 Ligase, inhibitors, activators


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