Free shipping on all orders over $ 500

(E/Z)-4-Hydroxytamoxifen

Cat. No. M7839
(E/Z)-4-Hydroxytamoxifen Structure
Synonym:

Afimoxifene

Size Price Availability Quantity
5mg USD 95.4  USD106 In stock
10mg USD 189  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.51
Formula C26H29NO2
CAS Number 68392-35-8
Purity >99%
Solubility Methanol 10 mg/mL
DMSO 60 mg/mL
Storage at -20°C
Related Estrogen Receptor Products
27-Hydroxycholesterol

27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor.

SAR439859 (Amcenestrant)

SAR439859 (Amcenestrant) is an orally active, nonsteroidal and selective degrader of estrogen receptor, it is also a potent antagonist of ER with EC50 of 0.2 nM for ERα degradation.

4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator.

Methylpiperidino pyrazole

Methylpiperidino pyrazole (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.

Endoxifen E-isomer hydrochloride

Endoxifen E-isomer hydrochloride is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: (E/Z)-4-Hydroxytamoxifen, Afimoxifene supplier, Estrogen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.