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Dulaglutide (Activated main chain)

Cat. No. M1601
Dulaglutide (Activated main chain) Structure
Size Price Availability Quantity
5mg USD 1500  USD1500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dulaglutide (Activated main chain) is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) consisting of GLP-1(7-37) covalently linked to an Fc fragment of human IgG4. Dulaglutide binds to glucagon-like peptide 1 receptors, slowing gastric emptying and increases insulin secretion by pancreatic Beta cells. Simultaneously the compound reduces the elevated glucagon secretion by inhibiting alpha cells of the pancreas. GLP-1 is normally secreted by L cells of the gastrointestinal mucosa in response to a meal.

Sequence: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Gly-Gly

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3213.2
Formula
CAS Number 923950-08-7
Purity >98%
Solubility Soluble in water
Storage at -20°C
References

[1] Tibble CA, et al. Expert Rev Endocrinol Metab. Longer acting GLP-1 receptor agonists and the potential for improved cardiovascular outcomes: a review of current literature.

[2] Nadkarni P, et al. Prog Mol Biol Transl Sci. Regulation of glucose homeostasis by GLP-1.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dulaglutide (Activated main chain) supplier, Glucagon Receptor, inhibitors

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