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Doxycycline monohydrate

Cat. No. M2652
Doxycycline monohydrate Structure
Size Price Availability Quantity
50mg USD 32  USD40 In stock
100mg USD 40  USD50 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Doxycycline monohydrate is a tetracycline antibiotic that commonly used to treat a variety of infections and MMP inhibitor.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 462.45
Formula C22H24N2O8.H2O
CAS Number 17086-28-1
Purity >98%
Solubility DMSO 3 mg/mL
Storage at -20°C
References

[1] Mary Bohannon, et al. Topical doxycycline monohydrate hydrogel 1% targeting proteases/PAR2 pathway is a novel therapeutic for atopic dermatitis

[2] Anna Markowska, et al. Doxycycline, salinomycin, monensin and ivermectin repositioned as cancer drugs

[3] Amy Perlmutter, et al. Oracea (doxycycline monohydrate)

[4] J M Bonnetblanc. Doxycycline

[5] B A Cunha, et al. Doxycycline

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Keywords: Doxycycline monohydrate supplier, MMP, inhibitors

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