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Dovitinib lactate monohydrate

Cat. No. M3667

Dovitinib lactate monohydrate Structure
Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 240 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dovitinib lactate monohydrate (TKI258, CHIR-258) is a small-molecule multitargeted receptor tyrosine kinase inhibitor. Dovitinib lactate monohydrate (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 500.52
Formula C21H21FN6O.C3H6O3.H2O
CAS Number 915769-50-5
Purity >99%
Solubility DMSO
Water
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dovitinib lactate monohydrate supplier, VEGFR/PDGFR, inhibitors

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