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Dovitinib (TKI-258) Dilactic Acid

Cat. No. M5592
Dovitinib (TKI-258) Dilactic Acid Structure
Size Price Availability Quantity
10mg USD 100 In stock
50mg USD 280 In stock
100mg USD 450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 572.59
Formula C21H21FN6O.2C3H6O3
CAS Number 852433-84-2
Purity >98%
Solubility 90 mg/mL in DMSO
Storage at -20°C
References

Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma.
Huynh H, et al. J Hepatol. 2012 Mar;56(3):595-601. PMID: 22027573.

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Keywords: Dovitinib (TKI-258) Dilactic Acid supplier, VEGFR/PDGFR, inhibitors

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