Free shipping on all orders over $ 500

Dorzagliatin

Cat. No. M10047
Dorzagliatin Structure
Synonym:

HMS5552; RO5305552; Sinogliatin

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 183  USD183 In stock
25mg USD 280  USD280 In stock
50mg USD 450  USD450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a glucokinase (GK) activator, which improves glycaemic control and pancreatic β-cell function for type 2 diabetes.

Chemical Information
Molecular Weight 462.93
Formula C22H27ClN4O5
CAS Number 1191995-00-2
Solubility (25°C) DMSO 83 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Li, et al. Pharmαzιe. Recent clinιcαl advances of glucoκinase activators in the treαtment of diabetes mellitus type 2

[2] Xiao-Xue Zhu, et al. Diabetes Obes Metab. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection

Related Glucokinase (GK) Products
AZD1092

AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM.

GKM-001

GKM-001 is a glucokinase (GK) activator that can be used in studies related to type 2 diabetes.

TMG-123

TMG-123 is a glucokinase (GK) activator that can be used in studies related to type 2 diabetes.

PB-201

PB-201 is a glucokinase activator (GKA) that can be used in studies related to type 2 diabetes.

MK-0941 free base 

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

  Catalog
Abmole Inhibitor Catalog




Keywords: Dorzagliatin, HMS5552; RO5305552; Sinogliatin supplier, Glucokinase (GK), inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.