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Donepezil hydrochloride

Cat. No. M3601
Donepezil hydrochloride Structure
Synonym:

E2020,Aricept

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 40  USD40 In stock
50mg USD 60  USD60 In stock
100mg USD 90  USD90 In stock
200mg USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

Donepezil hydrochloride is a centrally acting reversible acetylcholinesterase inhibitor (AChEI) with an IC50 of 12.3 nM. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase levels of cortical acetylcholine. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Lister Hooded rats
Formulation 0.9% w:v NaCl (saline)
Dosages 18 μM/kg
Administration Administered via i.p. or p.o.
Chemical Information
Molecular Weight 416
Formula C24H29NO3.HCl
CAS Number 120011-70-3
Solubility (25°C) Water 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zahra Soraya, et al. Donepezil hydrochloride as a novel inducer for osteogenic differentiation of mesenchymal stem cells on PLLA scaffolds in vitro

[2] Arnavaz Hajizadeh Barfejani, et al. Donepezil in the treatment of ischemic stroke: Review and future perspective

[3] Jiaxun Guo, et al. Memantine, Donepezil, or Combination Therapy-What is the best therapy for Alzheimer's Disease? A Network Meta-Analysis

[4] Takehiro Kawashiri, et al. Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

[5] Nan Zhang, et al. Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients

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Keywords: Donepezil hydrochloride, E2020,Aricept supplier, AChR/AChE, inhibitors, activators


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