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Docusate Sodium

Cat. No. M5589
Docusate Sodium Structure
Synonym:

Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate

Size Price Availability Quantity
100mg USD 75 In stock
500mg USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Docusate Sodium is a laxative used to treat constipation, for constipation due to the use of opiates it maybe used with a stimulant laxative, can be taken by mouth or rectally.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 444.56
Formula C20H37O7S.Na
CAS Number 577-11-7
Purity >99%
Solubility 88 mg/mL in DMSO
Storage at -20°C
References

Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review.
Ruston T, et al. Can Oncol Nurs J. 2013 Autumn;23(4):236-46. PMID: 24428006.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Docusate Sodium, Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate supplier, Opioid Receptor, inhibitors

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