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DMH1

Cat. No. M2647
DMH1 Structure
Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 85 In stock
50mg USD 300 In stock
100mg USD 480 In stock
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Quality Control
Biological Activity

DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.

Customer Product Validations & Biological Datas
Source Adv Healthc Mater (2017). Figure 1. DMH1
Method RT-PCR
Cell Lines hMSCs
Concentrations 50 μm
Incubation Time 0, 3, and 14 d
Results To evaluate the necessity of ERK1/2 phosphorylation on osteogenic gene expression, PD98059, a selective MEK1/2 inhibitor was used to treat hMSCs cultured on Col-GAG and MC-GAG and quantitative reverse-transcriptase polymerase chain reactions (RT-PCR) was performed in the same manner as the DMH1 experiment.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 380.44
Formula C24H20N4O
CAS Number 1206711-16-1
Purity 99.86%
Solubility DMSO 22 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DMH1 supplier, Autophagy, inhibitors

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