DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
|Source||Adv Healthc Mater (2017). Figure 1. DMH1|
|Incubation Time||0, 3, and 14 d|
|Results||To evaluate the necessity of ERK1/2 phosphorylation on osteogenic gene expression, PD98059, a selective MEK1/2 inhibitor was used to treat hMSCs cultured on Col-GAG and MC-GAG and quantitative reverse-transcriptase polymerase chain reactions (RT-PCR) was performed in the same manner as the DMH1 experiment.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 22 mg/mL|
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