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DM1-SMCC

Cat. No. M9036
DM1-SMCC Structure
Synonym:

SMCC-DM1

Size Price Availability Quantity
5mg USD 330 In stock
10mg USD 510 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC. DM1 is an antibody-conjugatable maytansinoid which can overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1 binds at the tips of microtubules and suppresses the dynamicity of microtubules.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1072.61
Formula C51H66ClN5O16S
CAS Number 1228105-51-8
Purity >99%
Solubility DMSO 10 mM
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DM1-SMCC, SMCC-DM1 supplier, inhibitors

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