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DL-TBOA

Cat. No. M10023
DL-TBOA Structure
Synonym:

DL-Threo-Beta-Benzyloxyaspartic acid

Size Price Availability
5mg USD 500  USD500 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 239.22
Formula C11H13NO5
CAS Number 205309-81-5
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] Elena Pedraz-Cuesta, et al. BMC Cancer. The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

[2] Y Shigeri, et al. J Neurochem. Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5)

[3] K Shimamoto, et al. Mol Pharmacol. DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

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Keywords: DL-TBOA, DL-Threo-Beta-Benzyloxyaspartic acid supplier, EAAT, inhibitors

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