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DL-Buthionine-(S,R)-sulfoximine

Cat. No. M13545
DL-Buthionine-(S,R)-sulfoximine Structure
Synonym:

Buthionine sulfoximine; BSO

Size Price Availability Quantity
100mg USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 222.31
Formula
CAS Number 5072-26-4
Purity >99%
Solubility Water 25 mg/mL
Storage at -20°C
References

[1] Gabriela Diaz de Barboza, et al. World J Gastroenterol. Oxidative stress, antioxidants and intestinal calcium absorption

[2] Mark F Belmonte, et al. Plant Cell Rep. Applications of DL-buthionine-[S,R]-sulfoximine deplete cellular glutathione and improve white spruce (Picea glauca) somatic embryo development

[3] A Marchionatti, et al. Comp Biochem Physiol C Toxicol Pharmacol. DL-Buthionine-S,R-sulfoximine affects intestinal alkaline phosphatase activity

[4] E P Kable, et al. Cancer Res. Sensitivity of human melanoma cells to L-dopa and DL-buthionine (S,R)-sulfoximine

[5] M F Chen, et al. Cancer Lett. Effect of DL-buthionine-S,R-sulfoximine on 1,2-dimethyl-hydrazine-induced colonic tumors in rats

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Keywords: DL-Buthionine-(S,R)-sulfoximine, Buthionine sulfoximine; BSO supplier, Ferroptosis, inhibitors

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