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DL-2-Amino-5-phosphonopentanoic acid

Cat. No. M9894
DL-2-Amino-5-phosphonopentanoic acid Structure
Synonym:

APV

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25mg USD 400  USD400 4-7 Days
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Quality Control & Documentation
Biological Activity

DL-2-Amino-5-phosphonopentanoic acid has been used in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses. DL-2-Amino-5-phosphonopentanoic acid has been used in growth medium for inhibition of electrical activity in the neuronal network.

Chemical Information
Molecular Weight 197.13
Formula C5H12NO5P
CAS Number 76326-31-3
Form Solid
Solubility (25°C) Water 5 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tomomi Ohara, et al. A simple method for the determination of glyphosate, glufosinate and their metabolites in biological specimen by liquid chromatography/tandem mass spectrometry: an application for forensic toxicology

[2] Marie A McGee, et al. Ethanol attenuates peripheral NMDAR-mediated vascular oxidative stress and pressor response

[3] A Nazarian, et al. Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P

[4] V Yarotskyy, et al. Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine

[5] M Arslan, et al. DL-2-amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat

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Keywords: DL-2-Amino-5-phosphonopentanoic acid, APV supplier, GluR, inhibitors, activators


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