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DiOC6(3)(iodide 3,3' -dihexyl carbonyl cyanine) is a carbonyl cyanine dye that can be used to detect changes in mitochondrial membrane potential. Fluorescent green. It can be used to look at cell membranes, lipids. Store at room temperature away from light. DiOC6 (3) can stain endoplasmic reticulum (Golgi apparatus) of living and fixed cells, as well as vesicle membranes and mitochondria at high concentrations. At lower concentrations, mitochondria were selectively stained. DiOC6(3) can be used to label viable cells; however, due to the rapid breakdown of photodynamic toxicity, labeled cells are exposed to light for only a short time. DiOC6(3) has been used to study the interactions and dynamics of endoplasmic reticulum (ER) structure in neurons and yeast cells. DiOC6(3) can stain the yeast nuclear membrane specifically and sensitively enough to uncover changes in the nuclear membrane (known as Karmellae) when the dye concentration is elevated or in certain respiratory defective yeast strains.
Front Bioeng Biotechnol. 2023 Feb 21;11:1098172.
Extracellular vesicles secreted by human gingival mesenchymal stem cells promote bone regeneration in rat femoral bone defects
DiOC6(3) iodide purchased from AbMole
| Molecular Weight | 572.52 |
| Formula | C29H37IN2O2 |
| CAS Number | 53213-82-4 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Vasileios Fotopoulos. Plant Signal Behav. Never say dye: new roles for an old fluorochrome
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