Free shipping on all orders over $ 500


Cat. No. M3968
Dihydromyricetin Structure


Size Price Availability Quantity
10mM*1mL In DMSO USD 100 In stock
5mg USD 120 In stock
10mg USD 180 In stock
50mg USD 300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dihydromyricetin (DHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects.Dihydromyricetin can protect HUVECs from oxidative stress damage, an effect that is mediated by the mitochondrial apoptotic pathways.Dihydromyricetin showed great antioxidative effect and would be a good natural antioxidant.Dihydromyricetin anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo, 10 μM in vitro), the benzodiazepine (BZ) antagonist. Dihydromyricetin competitively inhibited BZ-site [3H]flunitrazepam binding (IC50, 4.36 μM), suggesting DHM interaction with EtOH involves the BZ-sites on GABAARs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 320.25
Formula C15H12O8
CAS Number 27200-12-0
Purity >98%
Solubility DMSO 64mg/ml
Ethanol 64mg/ml
Storage at -20°C

Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways.
Hou X, et al. Life Sci. 2015 Mar 26. PMID: 25818185.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.
Hodek P, et al. Neuro Endocrinol Lett. 2014 Nov 30;35(Suppl 2):158-168. PMID: 25638381.

Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata.
Zhang YS, et al. Yao Xue Xue Bao. 2003 Apr;38(4):241-4. PMID: 12889119.

Dihydromyricetin As A Novel Anti-Alcohol Intoxication Medication.
Yi Shen, et al. J Neurosci. 2012 Jan 4;32(1): 390–401. PMID: 3292407.

Related GABA Receptor Products

ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.


LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator.

AOA hemihydrochloride

Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.

Chlormethiazole hydrochloride

Chlormethiazole hydrochloride is a GABAA agonist; glycine receptor modulator.

Tiagabine HCl

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Abmole Inhibitor Catalog 2017

Keywords: Dihydromyricetin, Ampeloptin,DMY,DHM supplier, GABA Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.