Dihydromyricetin (DHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects.Dihydromyricetin can protect HUVECs from oxidative stress damage, an effect that is mediated by the mitochondrial apoptotic pathways.Dihydromyricetin showed great antioxidative effect and would be a good natural antioxidant.Dihydromyricetin anti-alcohol effects on both behavior and CNS neurons were antagonized by flumazenil (10 mg/kg in vivo, 10 μM in vitro), the benzodiazepine (BZ) antagonist. Dihydromyricetin competitively inhibited BZ-site [3H]flunitrazepam binding (IC50, 4.36 μM), suggesting DHM interaction with EtOH involves the BZ-sites on GABAARs.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways.
Hou X, et al. Life Sci. 2015 Mar 26. PMID: 25818185.
Effect of dihydromyricetin on benzo[a]pyrene activation in rats.
Hodek P, et al. Neuro Endocrinol Lett. 2014 Nov 30;35(Suppl 2):158-168. PMID: 25638381.
Antioxidation properties and mechanism of action of dihydromyricetin from Ampelopsis grossedentata.
Zhang YS, et al. Yao Xue Xue Bao. 2003 Apr;38(4):241-4. PMID: 12889119.
Dihydromyricetin As A Novel Anti-Alcohol Intoxication Medication.
Yi Shen, et al. J Neurosci. 2012 Jan 4;32(1): 390–401. PMID: 3292407.
|Related GABA Receptor Products|
Zolpidem is a benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors.
Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis.
Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.