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Dihexa

Cat. No. M9158
Dihexa Structure
Synonym:

PNB-0408; Hexanoyl-Tyr-Ile-Ahx-NH2

Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 260 In stock
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Quality Control
Biological Activity

Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog, exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM. Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 504.66
Formula C27H44N4O5
CAS Number 1401708-83-5
Purity >98%
Solubility DMSO: ≥ 27 mg/mL
Storage at -20°C
References

The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
Benoist CC, et al. J Pharmacol Exp Ther. 2014 Nov;351(2):390-402. PMID: 25187433.

Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
McCoy AT, et al. J Pharmacol Exp Ther. 2013 Jan;344(1):141-54. PMID: 23055539.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dihexa, PNB-0408; Hexanoyl-Tyr-Ile-Ahx-NH2 supplier, c-Met, inhibitors

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