DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. DIDS sodium salt is also an anion transport inhibitor, which inhibits the ClC-Ka chloride channel and the bacterial ClC-ec1Cl-/H+ exchanger with IC50s of 100 μM and ~300 μM, respectively. DIDS reduced the amplitude of spontaneous transient inward currents (STICs) in a concentration-dependent manner with IC50 value of 2.1 x 10-4 M for STICs. Moreover, DIDS was investigated for its action on contraction of cerebral artery smooth muscle cells. DIDS showed a vasodilator effect on pressure-constricted arteries with IC50 of 69 ± 14 μM.
Molecular Weight | 498.48 |
Formula | C16H8N2Na2O6S4 |
CAS Number | 67483-13-0 |
Form | Solid |
Solubility (25°C) | DMSO ≥ 25 mg/mL |
Storage | -20°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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