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Diclofenac

Cat. No. M5572
Diclofenac  Structure
Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Diclofenac (diclofenac) is a COX inhibitor and has an IC50 of 60 and 220 nM for sheep COX-1 and -2, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 296.15
Formula C14H11Cl2NO2
CAS Number 15307-86-5
Purity >99%
Solubility 3.5 mg/mL in DMSO
Storage at -20°C
References

Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology.
Altman R, et al. Drugs. 2015 May;75(8):859-77. PMID: 25963327.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Diclofenac supplier, COX, inhibitors

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