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Diclofenac Epolamine

Cat. No. M20939
Diclofenac Epolamine Structure
Synonym:

DHEP, DIEP, diclofenac hydroxyethylpyrrolidine

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 411.32
Formula C20H24Cl2N2O3
CAS Number 119623-66-4
Purity >99%
Solubility DMSO 82 mg/mL
Water 82 mg/mL
Storage at -20°C
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Keywords: Diclofenac Epolamine, DHEP, DIEP, diclofenac hydroxyethylpyrrolidine supplier, Immunology/Inflammation, inhibitors

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