Free shipping on all orders over $ 500

Dibucaine

Cat. No. M5570
Dibucaine Structure
Size Price Availability Quantity
100mg USD 80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dibucaine is a local anesthetic of the amide type now generally used for surface anesthesia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 343.46
Formula C20H29N3O2
CAS Number 85-79-0
Purity >98%
Solubility 36 mg/mL in DMSO
Storage at -20°C
References

A competitive strategy based on cucurbit[7]uril supramolecular interaction for simple and sensitive detection of dibucaine.
Li Y, et al. Talanta. 2015 Jan;132:653-7. PMID: 25476359.

Related Sodium Channel Products
PF-05089771

PF-05089771 is a selective Nav1.7 channel blocker that interacts with the voltage-sensor domain (VSD) of domain IV.

PF-01247324

PF-01247324 is a novel selective and orally bioavailable Nav 1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel.

GS967

GS967, also known as GS-458967, is a potent and selective blocker of cardiac late sodium current (late INa) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.

PF-05089771 Tosylate

PF-05089771 Tosylate is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.

Tenapanor

Tenapanor is an inhibitor of the Na+/H+ exchanger NHE3 with IC50 values of 5 and 10 nM against human and Rat NHE3, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dibucaine supplier, Sodium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.