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Diazoxide

Cat. No. M5569

Diazoxide Structure

Synonym: Sch-6783, SRG-95213, Proglycem

Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 230.67
Formula C8H7ClN2O2S
CAS Number 364-98-7
Purity >99%
Solubility 46 mg/mL in DMSO
Storage at -20°C
References

Diazoxide attenuates autoimmune encephalomyelitis and modulates lymphocyte proliferation and dendritic cell functionality.
Virgili N, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):558-68. PMID: 24939091.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Diazoxide, Sch-6783, SRG-95213, Proglycem supplier, Potassium Channel, inhibitors

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