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Dexmedetomidine HCl

Cat. No. M5565
Dexmedetomidine HCl Structure
Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 236.74
Formula C13H17ClN2
CAS Number 145108-58-3
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Keating GM, et al. Drugs. 2015 Jul;75(10):1119-30. PMID: 26063213.

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