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Deutetrabenazine

Cat. No. M6184
Deutetrabenazine Structure
Size Price Availability
5mg USD 450 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Deutetrabenazine is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 323.46
Formula C19H21D6NO3
CAS Number 1392826-25-3
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD study.
Fernandez HH, et al. Neurology. 2017 May 23;88(21):2003-2010. PMID: 28446646.

Deutetrabenazine-Not a Revolution but Welcome Evolution for Treating Chorea in Huntington Disease.
Reilmann R, et al. JAMA Neurol. 2016 Dec 1;73(12):1404-1406. PMID: 27749952.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Deutetrabenazine supplier, inhibitors

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